South Park VS The Ponies is a game made by Paper Studios. In the gameplay, it is simply South Park is the protagonist and MLP is the antagonist.
South Park has been raided by MLP, and the main characters of South Park must stop MLP from killing all the characters and people in the South Park universe.
The first protagonist.
The second protagonist.
The third protagonist.
The fourth protagonist.
An unlockable, fifth protagonist.
Simply the main characters of MLP are the bosses.
The first boss.